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Symbol Name ID |
Ccr2
C-C motif chemokine receptor 2 MGI:106185 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Eosinophilia |
Increased T cell count |
Leukopenia |
Severe periodontitis |
Keratoconjunctivitis sicca |
Abnormal lymph node morphology |
Lymphadenopathy |
Uveitis |
Erythema nodosum |
Maculopapular exanthema |
Autoimmunity |
Asthma |
| Disease(s) Associated with CCR2 | ||||||||||||
| aggressive periodontitis | ||||||||||||
| asthma | ||||||||||||
| sarcoidosis | ||||||||||||
| type 1 diabetes mellitus |
| Mouse Phenotypes | immune system phenotype |
abnormal osteoclast differentiation |
abnormal dendritic cell chemotaxis |
abnormal macrophage chemotaxis |
impaired macrophage chemotaxis |
abnormal leukocyte migration |
abnormal cellular extravasation |
impaired leukocyte tethering or rolling |
abnormal leukocyte adhesion |
decreased T cell proliferation |
decreased splenocyte proliferation |
decreased susceptibility to induced colitis |
increased susceptibility to induced colitis |
enlarged spleen |
increased eosinophil cell number |
decreased neutrophil cell number |
decreased CD11b-high dendritic cell number |
increased CD11b-high dendritic cell number |
increased dendritic cell number |
increased B cell number |
decreased CD4-positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta T cell number |
decreased lymphocyte cell number |
decreased macrophage cell number |
decreased osteoclast cell number |
decreased monocyte cell number |
abnormal macrophage morphology |
abnormal osteoclast cell number |
abnormal monocyte morphology |
abnormal spleen morphology |
abnormal leukocyte physiology |
increased IgG level |
abnormal microglial cell physiology |
abnormal osteoclast physiology |
abnormal Langerhans cell physiology |
decreased susceptibility to type I hypersensitivity reaction |
abnormal immune serum protein physiology |
abnormal cytokine secretion |
abnormal chemokine secretion |
decreased interferon-gamma secretion |
increased interferon-gamma secretion |
decreased interleukin-2 secretion |
decreased interleukin-6 secretion |
increased tumor necrosis factor secretion |
decreased susceptibility to experimental autoimmune encephalomyelitis |
decreased acute inflammation |
decreased inflammatory response |
liver inflammation |
bronchiolitis |
increased susceptibility to bacterial infection |
increased susceptibility to Coronaviridae infection induced morbidity/mortality |
increased susceptibility to Coronaviridae infection |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ccr2em1(IMPC)H/Ccr2em1(IMPC)H | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ccr2tm1.1(CCR2)Rodb/Ccr2tm1.1(CCR2)Rodb | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ccr2tm1.1Dnc/Ccr2tm1.1Dnc | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ccr2tm1.1Mpa/Ccr2tm1.1Mpa | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ccr2tm1Blck/Ccr2tm1Blck | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ccr2tm1Brv/Ccr2tm1Brv | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ccr2tm1Ifc/Ccr2tm1Ifc | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ccr2tm1Mae/Ccr2tm1Mae | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ccr2tm1Ifc/Ccr2+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ccr2tm1Mpa/Ccr2tm1Mpa Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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